Masu bincike sun gano cewa farkon metabolite na THC ya kasance mai ƙarfi bisa bayanai daga ƙirar linzamin kwamfuta. Sabbin bayanan bincike suna ba da shawarar cewa babban metabolite da jini har yanzu suna aiki kuma mai tasiri kamar yadda Thc, idan ba haka ba ne. Wannan sabon binciken ya haifar da tambayoyi fiye da yadda yake amsawa. A cewar wani binciken da aka buga a kwanan nan a cikin Journal of Pharmacology da Experimental Therapeutics, da psychoactive metabolite na THC, 11-hydroxy-THC (11-OH-THC), yana da daidai ko mafi girma psychoactive iko fiye da THC (Delta-9 THC).
Binciken, mai taken "Madaidaicin maye na 11-Hydroxy-Delta-9-THC (11-OH-THC) Dangantakar da Delta-9-THC," yana nuna yadda THC metabolites ke riƙe aiki. An san cewa THC yana rushewa kuma yana haifar da sababbin mahadi masu ban sha'awa lokacin da ya lalata da kuma aiki a cikin jikin mutum. "A cikin wannan binciken, mun ƙaddara cewa farkon metabolite na THC, 11-OH-THC, yana nuna daidai ko mafi girma aiki fiye da THC a cikin tsarin aikin cannabinoid na linzamin kwamfuta lokacin da aka gudanar da shi kai tsaye, ko da la'akari da bambance-bambance a cikin hanyoyin gudanarwa, jima'i, pharmacokinetics, da pharmacodynamics, "in ji binciken. "Wadannan bayanan suna ba da mahimman bayanai game da ayyukan nazarin halittu na THC metabolites, suna sanar da bincike na cannabinoid na gaba, da kuma samfurin yadda cin abinci na THC da metabolism ke shafar amfani da cannabis na ɗan adam."
An gudanar da wannan binciken ne ta hanyar ƙungiyar daga Saskatchewan, Kanada, ciki har da Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, da Robert B. Laprairie. A cikin gwajin, masu bincike sun yi wa berayen allura tare da 11-hydroxy-THC kuma sun lura kuma sun yi nazarin tasirin wannan metabolite na THC idan aka kwatanta da mahaifar mahaifa, Delta-9 THC.
Masu binciken sun ci gaba da lura da cewa: "Wadannan bayanai sun nuna cewa a cikin gwajin wutsiya don fahimtar jin zafi, aikin 11-OH-THC shine 153% na THC, kuma a cikin gwajin catalepsy, aikin 11-OH-THC shine 78% na THC. Saboda haka, ko da la'akari da bambance-bambancen pharmacokinetic, 11-Other ko mafi girma fiye da aikin mahaifa. THC."
Don haka, binciken ya nuna cewa THC metabolite 11-OH-THC na iya taka muhimmiyar rawa a cikin ayyukan nazarin halittu na cannabis. Fahimtar ayyukansa lokacin gudanar da shi kai tsaye zai taimaka wajen bayyana nazarin dabba da ɗan adam a nan gaba. Rahoton ya ambaci cewa 11-OH-THC yana daya daga cikin manyan metabolites guda biyu da aka kafa bayan amfani da cannabis, ɗayan kuma shine 11-nor-9-carboxy-THC, wanda ba ya da hankali amma yana iya kasancewa cikin jini ko fitsari na dogon lokaci.
Dangane da Cibiyar Kula da Cututtuka da Cututtuka ta Amurka (CDC), tun farkon shekarun 1980, gwajin fitsari da farko an yi niyya ne akan 11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), metabolite na Delta-9-THC, wanda shine babban kayan aiki a cikin cannabis.
Rahoton ya nuna cewa ko da yake shan wiwi yana haifar da sakamako da sauri fiye da cinye kayan abinci na cannabis, adadin 11-OH-THC da aka samar ta hanyar sha ya fi na shan furannin cannabis. Rahoton ya nuna cewa wannan shine dalili guda daya da yasa abincin da aka sanya ta cannabis zai iya zama mai hankali da kuma haifar da rudani ga marasa shiri.
THC Metabolites da Gwajin Magunguna
Shaidu sun nuna cewa cannabis yana shafar masu amfani daban-daban dangane da hanyar gudanarwa. Wani bincike na 2021 da aka buga a cikin Mujallar Dindindin ya nuna cewa tasirin amfani da kayan abinci na cannabis ya fi na shan taba sigari saboda metabolism na 11-OH-THC.
"Rashin lafiyar THC ta hanyar tururi shine 10% zuwa 35%," masu binciken sun rubuta. "Bayan sha, THC yana shiga cikin hanta, inda mafi yawansu an kawar da su ko metabolized zuwa 11-OH-THC ko 11-COOH-THC, tare da sauran THC da metabolites na shiga cikin jini. Rabin rabin rayuwar THC na plasma a cikin masu amfani lokaci-lokaci shine kwanaki 1 zuwa 3, yayin da a cikin masu amfani na yau da kullun, zai iya zama tsawon kwanaki 5 zuwa 13.
Nazarin ya nuna cewa dadewa bayan tasirin psychoactive na cannabis ya ƙare, THC metabolites kamar 11-OH-THC na iya kasancewa cikin jini da fitsari na tsawon lokaci. Wannan yana haifar da ƙalubale ga daidaitattun hanyoyin gwaji ko direbobi da 'yan wasa suna da rauni saboda amfani da cannabis. Misali, masu bincike na Ostiraliya sun yi ƙoƙarin tantance lokacin lokacin da cannabis na iya lalata aikin tuƙi. A cikin wani yanayi, Thomas R. Arkell, Danielle McCartney, da Iain S. McGregor daga Lambert Initiative a Jami'ar Sydney sunyi nazarin tasirin cannabis akan iyawar tuki. Ƙungiyar ta yanke shawarar cewa cannabis yana lalata ikon tuƙi na sa'o'i da yawa bayan shan sigari, amma waɗannan lahani sun ƙare kafin a kawar da metabolites na THC daga jini, tare da metabolites suna dawwama a cikin jiki tsawon makonni ko watanni.
"Masu lafiya da ke amfani da samfuran da suka ƙunshi THC ya kamata su guje wa tuƙi da sauran ayyuka masu aminci (misali, injunan aiki), musamman a lokacin farkon jiyya da kuma sa'o'i da yawa bayan kowane kashi," marubutan sun rubuta. "Ko da marasa lafiya ba su ji rauni ba, za su iya gwada ingancin THC. Bugu da ƙari, marasa lafiyar cannabis a halin yanzu ba a keɓe su daga gwajin magungunan wayar hannu da kuma takunkumin shari'a."
Wannan sabon bincike akan 11-OH-THC ya nuna cewa ana buƙatar ƙarin karatu don zurfin fahimtar yadda metabolites na THC ke shafar jikin ɗan adam. Ta hanyar ci gaba da ƙoƙari ne kawai za mu iya tona asirin waɗannan mahalli na musamman.
Lokacin aikawa: Maris 21-2025